This subproject will focus on the neurobiology of a-synuclein (aSYN) and LRRK2. In particular, we will address:

1. a-SYN aggregation (WP1-3)
2. Role of oxidative stress and inflammation in a-SYN-mediated neurodegeneration (WP4)
3. Physiological and pathological function of the kinase activity of LRRK2 (WP5)
4. Kinase-unrelated pathological effects of LRRK2 (WP6)
5. Creation and evaluation of novel rat LRRK2 animal models (WP7)

 

Workpackages

 

Workpackage No	Work package title	Lead Participant No	Work Package Leader
1.1	Effects of oligomeric alpha-synuclein on cellular homeostasis	University of Aarhus	Poul Henning Jensen
1.2	Pathophysiology of secreted a-synuclein species	Biomedical Research Foundation of the Acadamy of Athens	Leonidas Stefanis
1.3	Identification of factors that influence a-synuclein oligomerization in cell culture and in vivo	Instituto de Medicina Molecular Lisbon	Tiago Outeiro
1.4	Role of oxidative stress and microglial response in a-synuclein-mediated nigral neurodegeneration	Lund University	Deniz Kirik
1.5	Examination of the role of LRRK2 in cellular pathways: focus on the kinase activity	Novartis AG	Georgio Rovelli
1.6	Beyond kinase activity: Examination of other factors influencing LRRK2 neurotoxicity	The Chancellor, Masters and Scholars of the University of Cambridge	David Rubinsztein
1.7	Development of a rat BAC model of LRRK2	University of Tuebingen	Olaf Riess