RESULTS and PUBLICATIONS
α-Synuclein impairs macroautopha gy: implications for Parkinson's disease
Journal of Cell Biology 190(6):10 23-37 1023-1037
20/09/2010
The Parkinson disease protein α-synuclein inhibits autophagy
Autophagy 7(4): 429–431 429-431
01/04/2011
The Parkinson's disease protein LRRK2 im pairs proteasome substrate clearance wit hout affecting proteasome catalytic activity
Cell Death and Disease 5;2:e19 6. doi: 10.1038/ cd dis.20 11.81. electroni c journal - Aug 25;2:
25/08/2011
N-terminal deletion does not affect alpha-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.
Journal of Neurochemistry pending pending
16/08/2011
Assessment of α-synuclein secretion in mouse and human brain parenchyma.
PLoS ONE 6(7):e222 25 1-9
14/07/2011
β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease.
Molecular Genetics and Metabolism 2011 Sep-Oct; 104(1-2):149-52. 149-152
24/06/2011
GBA-associated PD presents with nonmotor characteristics.
Neurology 77(3) 276-80
19/07/2011
Efficient transduction of dopaminergic neurons in rat substantia nigra by different adeno-associated viral vector serotypes.
Gene Therapy 18(5):517-27 417-27
18/05/2011
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance.
J. of Cell Science 124 (7) 11115-25
01/04/2011
Comparative analysis of different peptidyl-prolylisomerases reveals FK506-binding protein 12 as the most potent enhancer of α-synuclein aggregation.
J. Biol. Chem 286:26687-26701 26687-26701
29/07/2011
Genetic basis of Parkinson´s disease: inheritance, penetrance, and expression.
The Application of Clinical Genetics 4 2011:4; 67-80
31/05/2011
Milestones in PD Genetics.
Movement Disorders 6 26(6):104 2-1048
26/05/2011
Effective long-term subthalamic stimulatin in PARK8 positive Parkinson´s disease
Journal of Neurology 7 1205-7
01/07/2010
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects
Progress in brain research 2010;183 3-20
07/08/2010
Self estimated quality of life in monogenetic Parkinson´s disease.
Movement Disorders 1 182-190
01/01/2011
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
J Neurosci. 31(1) 157-163
05/01/2011
Regulation of PINK1-Parkin-mediated mitophagy
Autophagy 7(3) 266 - 278
01/03/2011
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Autophagy 6(7) 871 - 878
01/10/2011
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
Experimental Cell Research 316(7) 1213-1224
15/04/2010
Autophagy in Dementias
Brain Pathology 22 (1): 2012 Jan 99-109
15/01/2012 Blackwell Publishing
Mitochondrial quality control turns out tobe the principal suspect in parkin and PINK1-relate d autosomal recessive Parkinson’s disease.
Current Opinion in Neurobiology 23 (1) 100-108
15/02/2013 Elsevier Limited
Enlarged hyperechogen ic substantia nigraas a risk marker for Parkinson's disease
Movement Disorders 28(2) 216-219
28/02/2013 John Wiley and SonsInc.
GBA-associate d PD: Neurodegener ation, altered membrane metabolism, and lack ofenergy failure
Neurology 79(3) 213-220
17/07/2012 Lippincott Williamsand Wilkins
Genetic testing in neurological diseases10.1007
Journal of Neurology 259(6) 1249-54
01/06/2012 D.
LRRK2: Understanding the role of common and rare variants in Parkinson's disease
Movement Disorders 27(4) 475
01/04/2012 John Wiley and SonsInc.
Cerebrospinal fluid fatty acids in glucocerebro sidase-associ ated Parkinson's disease
Movement Disorders 27(2) 288-92
21/10/2011 John Wiley and SonsInc.
Clinical and brain imaging characteristi csin leucine-rich repeat kinase 2-associatedPD and asymptomatic mutation carriers
Movement Disorders 26(13) 2335-42
01/11/2011 John Wiley and SonsInc.
α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation inearly-stage Parkinson's disease
Human Molecular Genetics 21(14) 3173-92
15/07/2012 Oxford University Press
Dysregulated dopamine storage increasesthe vulnerabilit y to α-synuclein in nigralneurons
Neurobiology of Disease 47(3) 367-77
01/09/2012 Academic Press Inc.
Loss-of-funct ion rodent models for parkinand PINK1
Journal of Parkinson's Disease 1(3):2011 229-51
01/03/2011 IOS Press
N-terminal deletion does not affect α-synuclein membrane binding, self-associat ion and toxicity in human neuroblastom a cells, unlike yeast.
Journal of Neurochemistry 119(2) 389-97
01/10/2011 Blackwell Publishing
Characterisat ion of peripheral haematopoieti c stem cells and monocytes in Parkinson’s disease
Movement Disorders na na
07/02/2013 John Wiley and SonsInc.
Loss of DJ-1 protein stability and cytoprotecti ve function by Parkinson's disease-asso ciated proline-158 deletion
Journal of Neurochemistry 2 / 125 314 - 327
15/01/2013 Blackwell Publishing
FAS-Dependent Cell Death in α-SynucleinTransgenic Oligodendrocy te Models ofMultiple System Atrophy
PLoS One 1 / 8 e55243 -
25/01/2013 Public Library of Science
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN -dependent mitochondrial clearance
Autophagy 11 / 9 1801 - 1817
05/09/2013 Landes Bioscience
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN -dependent mitochondrial clearance
Autophagy 11 / 9 1801 - 1817
01/11/2013 Landes Bioscience
Phosphorylate d -Synuclein in Parkinson'sDisease
Science Translational Medicine 121 / 4 1-8
15/02/2012 American Associationfor the Advancementof Science
Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo
Journal of Neuroscience 10 / 32 3301 - 3305
07/03/2012 Society for Neuroscience
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
Brain; a journal of neurology 2 / 136 412 - 432
01/02/2013 Oxford University Press
Genetics of Parkinson disease and othermovement disorders
Current Opinion in Neurology 4 / 25 466 - 474 (9)
25/08/2012 Lippincott Williamsand Wilkins
Depression and quality of life in monogenic compared to idiopathic, early-onsetParkinson's disease
Movement Disorders 6 / 27 754 - 759
27/05/2012 John Wiley and SonsInc.
Autosomal dominant Parkinson’s disease in a large German pedigree
Acta Neurologica Scandinavica 2 / 126 129 - 137 (8)
01/08/2012 Blackwell Publishing
RIPOTENT STEM CELL-DERIVED NEUPhosphatase and Tensin Homolog (PTEN)-induce d Putative Kinase 1 (PINK1)-depe ndent Ubiquitinatio n of Endogenous Parkin Attenuates Mitophagy:STUDY IN HUMAN PRIMARY FIBROBLASTS AND INDUCED PLURONS
Journal of Biological Chemistry 4 / 288 2223 - 2237(15)
25/01/2013 American Society forBiochemistry and Molecular Biology Inc.
Next-Generati on Phenotyping Using theParkin Example
Archives of Neurology 9 / 70 1186 -1191 (6)
01/09/2013 American MedicalAssociation
Cerebrospinal fluid biomarkers in Parkinson disease
Nature Reviews Neurology 3 / 9 131 - 140
19/02/2013 Nature Publishing Group
TRAP1 rescues PINK1 loss-of-func tionphenotypes
Human Molecular Genetics 14 / 22 2829 - 2841
15/07/2013 Oxford University Press
The Parkinson's disease–linke d proteinsFbxo7 and Parkin interact to mediate mitophagy
Nature Neuroscience 9 / 16 1257 - 1265
11/08/2013 Nature Publishing Group
Comparative Analysis of Different Peptidyl-Pro lyl Isomerases Reveals FK506-bindin g Protein 12 as the Most Potent Enhancerof -Synuclein Aggregation
Journal of Biological Chemistry 30 / 286 26687 - 26701
29/07/2011 American Society forBiochemistry and Molecular Biology Inc.
Loss-of-funct ion rodent models for parkinand PINK1
Journal of Parkinson's Disease 1(3) 229-251
01/03/2011 IOS Press
PLK2 Modulates α-Synuclein Aggregationin Yeast and Mammalian Cells
Molecular Neurobiology 3 / 48 854 - 862
17/05/2013 Humana Press
Heat-mediated enrichment of α-synucleinfrom cells and tissue for assessing post-translat ional modification s
Journal of Neurochemistr y 5 / 126 673 - 684
25/04/2013 Blackwell Publishing
LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models
Journal of Molecular Medicine 4 / 91 513 - 522
27/11/2012 Springer Verlag
GBA-associate d PD: Neurodegener ation, altered membrane metabolism, and lack ofenergy failure
Neurology 3 / 79 213 - 220
20/06/2012 Lippincott Williamsand Wilkins
SNCA: Major genetic modifier of age at onset of Parkinson's disease
Movement Disorders 9 / 28 1217 - 1221
04/05/2013 John Wiley and SonsInc.
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependen t Changes in Gene Expression
Cell Stem Cell 12(3) 354-367
07/03/2013 Cell Press
Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma
PLoS One 7 / 6 1-9
14/07/2011 Public Library of Science