News

“End of the project”

30.09.2013

RESULTS and PUBLICATIONS

 

Winslow AR, Chen CW, Corrochan o S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein D C.

α-Synuclein impairs macroautopha gy: implications for Parkinson's disease

Journal of Cell Biology 190(6):10 23-37 1023-1037
20/09/2010

Ashley R Winslow and David C Rubinsztein

The Parkinson disease protein α-synuclein inhibits autophagy

Autophagy 7(4): 429–431 429-431
01/04/2011

Lichtenberg M, Mansilla A , Zecchini VR, Fleming A, Rubinsztein DC

The Parkinson's disease protein LRRK2 im pairs proteasome substrate clearance wit hout affecting proteasome catalytic activity

Cell Death and Disease 5;2:e19 6. doi: 10.1038/ cd dis.20 11.81. electroni c journal - Aug 25;2:
25/08/2011

Katerina Vamvaca

N-terminal deletion does not affect alpha-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.

Journal of Neurochemistry pending pending
16/08/2011

Evangelia Emmanouilidou

Assessment of α-synuclein secretion in mouse and human brain parenchyma.

PLoS ONE 6(7):e222 25 1-9
14/07/2011

Marina Moraitou

β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease.

Molecular Genetics and Metabolism 2011 Sep-Oct; 104(1-2):149-52. 149-152
24/06/2011

Kathrin Brockmann

GBA-associated PD presents with nonmotor characteristics.

Neurology 77(3) 276-80
19/07/2011

Van der Perren A., Toelen J., Coun F., Van den Haute C., Heeman B., Carlon M., Reumers V., Vandenberghe L.H., Wilson J.M., Debyser Z. and Baekelan dt V.

Efficient transduction of dopaminergic neurons in rat substantia nigra by different adeno-associated viral vector serotypes.

Gene Therapy 18(5):517-27 417-27
18/05/2011

Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V.

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance.

J. of Cell Science 124 (7) 11115-25
01/04/2011

Deleersnijder A., Desender L., Munck S., Pottel H., Buée L., Debyser Z., Baekelandt V. and Gerard M.

Comparative analysis of different peptidyl-prolylisomerases reveals FK506-binding protein 12 as the most potent enhancer of α-synuclein aggregation.

J. Biol. Chem 286:26687-26701 26687-26701
29/07/2011

Claudia Schulte

Genetic basis of Parkinson´s disease: inheritance, penetrance, and expression.

The Application of Clinical Genetics 4 2011:4; 67-80
31/05/2011

Thomas Gasser

Milestones in PD Genetics.

Movement Disorders 6 26(6):104 2-1048
26/05/2011

Sorin Breit

Effective long-term subthalamic stimulatin in PARK8 positive Parkinson´s disease

Journal of Neurology 7 1205-7
01/07/2010

Thomas Gasser

Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects

Progress in brain research 2010;183 3-20
07/08/2010

Susanne Gräber

Self estimated quality of life in monogenetic Parkinson´s disease.

Movement Disorders 1 182-190
01/01/2011

Imam SZ

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

J Neurosci. 31(1) 157-163
05/01/2011

Springer W

Regulation of PINK1-Parkin-mediated mitophagy

Autophagy 7(3) 266 - 278
01/03/2011

Geisler S

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

Autophagy 6(7) 871 - 878
01/10/2011

Kieper N

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

Experimental Cell Research 316(7) 1213-1224
15/04/2010

Christine L. Kragh

Autophagy in Dementias

Brain Pathology 22 (1): 2012 Jan 99-109
15/01/2012 Blackwell Publishing

Olga Corti, Alexis Brice

Mitochondrial quality control turns out tobe the principal suspect in parkin and PINK1-relate d autosomal recessive Parkinson’s disease.

Current Opinion in Neurobiology 23 (1) 100-108
15/02/2013 Elsevier Limited

Berg D., Brockmann K et.al.

Enlarged hyperechogen ic substantia nigraas a risk marker for Parkinson's disease

Movement Disorders 28(2) 216-219
28/02/2013 John Wiley and SonsInc.

Kathrin Brockmann

GBA-associate d PD: Neurodegener ation, altered membrane metabolism, and lack ofenergy failure

Neurology 79(3) 213-220
17/07/2012 Lippincott Williamsand Wilkins

Biskup S., Gasser T.

Genetic testing in neurological diseases10.1007

Journal of Neurology 259(6) 1249-54
01/06/2012 D.

Sharma M, Kruger R, Gasser T

LRRK2: Understanding the role of common and rare variants in Parkinson's disease

Movement Disorders 27(4) 475
01/04/2012 John Wiley and SonsInc.

Schmid Sp, Brockmann K, et.al.

Cerebrospinal fluid fatty acids in glucocerebro sidase-associ ated Parkinson's disease

Movement Disorders 27(2) 288-92
21/10/2011 John Wiley and SonsInc.

Kathrin Brockman n

Clinical and brain imaging characteristi csin leucine-rich repeat kinase 2-associatedPD and asymptomatic mutation carriers

Movement Disorders 26(13) 2335-42
01/11/2011 John Wiley and SonsInc.

Isabel Lastres-Becker

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation inearly-stage Parkinson's disease

Human Molecular Genetics 21(14) 3173-92
15/07/2012 Oxford University Press

Ayse Ulusoy

Dysregulated dopamine storage increasesthe vulnerabilit y to α-synuclein in nigralneurons

Neurobiology of Disease 47(3) 367-77
01/09/2012 Academic Press Inc.

Oliveras-Salvá M and Van Rompuy AS

Loss-of-funct ion rodent models for parkinand PINK1

Journal of Parkinson's Disease 1(3):2011 229-51
01/03/2011 IOS Press

Vamvaca K

N-terminal deletion does not affect α-synuclein membrane binding, self-associat ion and toxicity in human neuroblastom a cells, unlike yeast.

Journal of Neurochemistry 119(2) 389-97
01/10/2011 Blackwell Publishing

Natalja Funk

Characterisat ion of peripheral haematopoieti c stem cells and monocytes in Parkinson’s disease

Movement Disorders na na
07/02/2013 John Wiley and SonsInc.

Emmy H. Rannikko , Louise Buur Vesterager, Jafar H. A. Shaik, Stephanie S. Weber, Elena M. Cornejo Castro, Karina Fog, Poul H.Jensen, Philipp J. Kahle

Loss of DJ-1 protein stability and cytoprotecti ve function by Parkinson's disease-asso ciated proline-158 deletion

Journal of Neurochemistry 2 / 125 314 - 327
15/01/2013 Blackwell Publishing

Christine L. Kragh, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH.

FAS-Dependent Cell Death in α-SynucleinTransgenic Oligodendrocy te Models ofMultiple System Atrophy

PLoS One 1 / 8 e55243 -
25/01/2013 Public Library of Science

Giulia Bertolin, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lombès A, Bulteau AL, Fon EA, BriceA, Corti O.

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN -dependent mitochondrial clearance

Autophagy 11 / 9 1801 - 1817
05/09/2013 Landes Bioscience

Giulia Bertolin

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN -dependent mitochondrial clearance

Autophagy 11 / 9 1801 - 1817
01/11/2013 Landes Bioscience

Y. Wang, ShiM, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM, Siderowf AD, Hurtig H, Litvan I, Schiess MC, PeskindER, MasudaM, HasegawaM, Lin X, Pan C, Galasko D, Goldstein DS, Jensen PH, Yang H, Cain KC, Zhang J.

Phosphorylate d -Synuclein in Parkinson'sDisease

Science Translational Medicine 121 / 4 1-8
15/02/2012 American Associationfor the Advancementof Science

E. Colla, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK.

Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo

Journal of Neuroscience 10 / 32 3301 - 3305
07/03/2012 Society for Neuroscience

S. Nuber, Harmuth F, Kohl Z, Adame A, Trejo M , Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahash i R, Winkler J, Masliah E, Riess O.

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

Brain; a journal of neurology 2 / 136 412 - 432
01/02/2013 Oxford University Press

Kishore R., Kumar, Lohmann K, Klein C

Genetics of Parkinson disease and othermovement disorders

Current Opinion in Neurology 4 / 25 466 - 474 (9)
25/08/2012 Lippincott Williamsand Wilkins

Meike Kasten, Kertelge L, Tadic V, Brüggemann N, Schmidt A, van der Vegt J, Siebner H, Buhmann C, Lencer R, Kumar KR, Lohmann K, Hagenah J, Klein C.

Depression and quality of life in monogenic compared to idiopathic, early-onsetParkinson's disease

Movement Disorders 6 / 27 754 - 759
27/05/2012 John Wiley and SonsInc.

N. Brüggemann, Külper W, Hagenah J, Bauer P, Pattaro C, Tadic V, Lohnau T, Winkler S, Tönnies H, Sprenger A, Pramstaller P, Rolfs A, Siebert R, Riess O, Vieregge P, Lohmann K, Klein C

Autosomal dominant Parkinson’s disease in a large German pedigree

Acta Neurologica Scandinavica 2 / 126 129 - 137 (8)
01/08/2012 Blackwell Publishing

A. Rakovic, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C

RIPOTENT STEM CELL-DERIVED NEUPhosphatase and Tensin Homolog (PTEN)-induce d Putative Kinase 1 (PINK1)-depe ndent Ubiquitinatio n of Endogenous Parkin Attenuates Mitophagy:STUDY IN HUMAN PRIMARY FIBROBLASTS AND INDUCED PLURONS

Journal of Biological Chemistry 4 / 288 2223 - 2237(15)
25/01/2013 American Society forBiochemistry and Molecular Biology Inc.

Anne Grünewald, Kasten M, Ziegler A, Klein C

Next-Generati on Phenotyping Using theParkin Example

Archives of Neurology 9 / 70 1186 -1191 (6)
01/09/2013 American MedicalAssociation

Lucilla Parnetti , Castrioto A, Chiasserini D, Persichetti E, Tambasco N, El-Agnaf O, Calabresi P

Cerebrospinal fluid biomarkers in Parkinson disease

Nature Reviews Neurology 3 / 9 131 - 140
19/02/2013 Nature Publishing Group

L. Zhang, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A

TRAP1 rescues PINK1 loss-of-func tionphenotypes

Human Molecular Genetics 14 / 22 2829 - 2841
15/07/2013 Oxford University Press

Victoria S Burchell, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H

The Parkinson's disease–linke d proteinsFbxo7 and Parkin interact to mediate mitophagy

Nature Neuroscience 9 / 16 1257 - 1265
11/08/2013 Nature Publishing Group

A. Deleersnijder, Van Rompuy AS, Desender L, Pottel H, Buée L, Debyser Z, Baekelan dtV, Gerard M

Comparative Analysis of Different Peptidyl-Pro lyl Isomerases Reveals FK506-bindin g Protein 12 as the Most Potent Enhancerof -Synuclein Aggregation

Journal of Biological Chemistry 30 / 286 26687 - 26701
29/07/2011 American Society forBiochemistry and Molecular Biology Inc.

Oliveras- Salvá M, Van Rompuy AS, Heeman B, Van den Haute C, Baekelandt V

Loss-of-funct ion rodent models for parkinand PINK1

Journal of Parkinson's Disease 1(3) 229-251
01/03/2011 IOS Press

Elisa Basso, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF

PLK2 Modulates α-Synuclein Aggregationin Yeast and Mammalian Cells

Molecular Neurobiology 3 / 48 854 - 862
17/05/2013 Humana Press

Hugo Vicente Miranda, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF

Heat-mediated enrichment of α-synucleinfrom cells and tissue for assessing post-translat ional modification s

Journal of Neurochemistr y 5 / 126 673 - 684
25/04/2013 Blackwell Publishing

Patrícia Silva Guerreiro, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

Journal of Molecular Medicine 4 / 91 513 - 522
27/11/2012 Springer Verlag

K. Brockmann, Ruediger Hilker, Ulrich Pilatus, Simon Baudrexe , Jorg Magerkurth, Ann-Kathrin Hauser, Claudia Schulte, Ilona Csoti, Caroline Denise Merten, Thomas Gasser, Daniela Bergand, Elke Hattingen

GBA-associate d PD: Neurodegener ation, altered membrane metabolism, and lack ofenergy failure

Neurology 3 / 79 213 - 220
20/06/2012 Lippincott Williamsand Wilkins

Kathrin Brockmann, Claudia Schulte, Ann-Kathrin Hauser, Peter Lichtner, Heiko Huber, Walter Maetzler, Daniela Berg, Thomas Gasser

SNCA: Major genetic modifier of age at onset of Parkinson's disease

Movement Disorders 9 / 28 1217 - 1221
04/05/2013 John Wiley and SonsInc.

Reinhardt P., Brockmann K, Gasser T.

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependen t Changes in Gene Expression

Cell Stem Cell 12(3) 354-367
07/03/2013 Cell Press

Evangelia Emmanouilidou, Elenis D, Papasilekas T, Stranjalis G, Gerozissis K, Ioannou PC, Vekrellis K

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

PLoS One 7 / 6 1-9
14/07/2011 Public Library of Science